Fig. 1. HMW-AGEs induce hypertrophy. (A) Heart weight/body weight (HW/BW, mg/g, p=0.0006, parametric unpaired t-test) and HW/tibia length (HW/TL, mg/cm, p=0.0021, parametric unpaired t-test) in control (N=16) and HMW-AGEs (N=17) animals. (B) Analysis of cardiomyocyte width (µm, p<0.0001, parametric unpaired t-test) and length (µm, p=0.9628, parametric unpaired t-test) in control (n_cells=203) and HMW-AGEs (n_cells=436). (C) Frequency distribution of cardiomyocyte width and length in both groups. Data are expressed as mean ± SEM. ** denotes p<0.001, *** denotes p<0.0001.